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Inform patients that: Tramadol Hydrochloride Extended-Release is for oral use only and may be swallowed full. The capsule really should not be chewed, dissolved, crushed or split. Tramadol Hydrochloride Extended-Launch may trigger seizures and/or serotonin syndrome with concomitant utilization of serotonergic brokers (like SRIs, NRIs, and triptans)